Drug details:
Molecular formula: C₂₉H₂₇ClN₂O₅S₂

Standard name: 2-[(3-chlorophenyl)methyl-[[5-(3,3-diphenylpropylsulfamoyl)thiophen-2-yl]methyl]amino]-2-oxoacetic acid

Synonyms:

[(3-chlorobenzyl)({5-[(3,3-diphenylpropyl)sulfamoyl]thiophen-2-yl}methyl)amino](oxo)acetic acid 2-((3-chlorobenzyl)((5-(N-(3,3-diphenylpropyl)sulfamoyl)thiophen-2-yl)methyl)amino)-2-oxoacetic acid

Curated SMILES: C1=CC=C(C=C1)C(CCNS(=O)(=O)C2=CC=C(S2)CN(CC3=CC(=CC=C3)Cl)C(=O)C(=O)O)C4=CC=CC=C4

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpB
Drug effect: Inhibits protein tyrosine phosphatase B (PtpB) to interfere with signal transduction pathways in macrophages.
Max phase: Preclinical (in vitro)
Publication:
Grundner C, et al., 2007. Structural basis for selective inhibition of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB. Structure 15(4):499-509.