Drug details:
Classification: Indolecarboxylic acids and derivatives; Indoles and derivatives; Organoheterocyclic compounds; Organic compounds;

Curated SMILES: C1CCCC2=C(CC1)C3=CC(=CC=C3N2C(=O)C4=CC=CS4)S(=O)(=O)O

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpB
Drug effect: Inhibits protein tyrosine phosphatase B (PtpB) to interfere with signal transduction pathways in macrophages.
Max phase: Preclinical (in vitro)
Publication:
Nören-Müller A, et al., 2006. Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. Proc Natl Acad Sci U S A 103(28):10606-11.