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3-decyl-1-(furan-2-carbonyl)-2-methylindole-5-sulfonic acid

Drug details:
Molecular formula: C24H31NO5S

Classification: Indolecarboxylic acids and derivatives; Indoles and derivatives; Organoheterocyclic compounds; Organic compounds;
Chemical structure:
Depiction based on curated SMILES CH 3 O O HO O O S CH 3 N

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpB
Drug effect: Inhibits protein tyrosine phosphatase B (PtpB) to interfere with signal transduction pathways in macrophages.
Max phase: Preclinical (in vitro)
Publication:
Nören-Müller A, et al., 2006. Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. Proc Natl Acad Sci U S A 103(28):10606-11.








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