Drug details:
Classification: Pyridoindoles; Indoles and derivatives; Organoheterocyclic compounds; Organic compounds;

Curated SMILES: [H][C@]12C=C(Cl)CC(C3=CC=C(Cl)C=C3)N1[C@@H](C(=O)O)CC1=C2NC2=C1C=CC=C2

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpB
Drug effect: Inhibits protein tyrosine phosphatase B (PtpB) to interfere with signal transduction pathways in macrophages.
Max phase: Preclinical (in vitro)
Publication:
Nören-Müller A, et al., 2006. Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis. Proc Natl Acad Sci U S A 103(28):10606-11.