Drug details:
Molecular formula: C₁₇H₁₄ClN₃O₂

Standard name: N-(5-chloro-2-methylphenyl)-2-(4-oxoquinazolin-3-yl)acetamide

Synonyms:

N-(5-chloro-2-methylphenyl)-2-(4-oxoquinazolin-3-yl)acetamide N-(5-chloro-2-methylphenyl)-2-(4-oxoquinazolin-3(4H)-yl)acetamide

Curated SMILES: CC1=C(C=C(C=C1)Cl)NC(=O)CN2C=NC3=CC=CC=C3C2=O

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Immune modulation
Target: CdnP
Drug effect: Inhibits bacterial phosphodiesterase (PDE) CdnP activity that responsible for cleaving bacterial c-di-AMP as well as host-derived cGAMP to blunt the host's response to infection.
Max phase: Preclinical (in vitro)
Publication:
Karanja CW, et al., 2021. Identification of a Mycobacterium tuberculosis Cyclic Dinucleotide Phosphodiesterase Inhibitor. ACS Infect Dis 7(2):309-317.