Drug details:
Molecular formula: C₂₁H₂₁N₅O₂

Standard name: [4-(dimethylamino)-2-pyridin-3-yl-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-(3-hydroxyphenyl)methanone

Curated SMILES: CN(C)C1=NC(=NC2=C1CCN(C2)C(=O)C3=CC(=CC=C3)O)C4=CN=CC=C4

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Immune modulation
Target: CdnP
Drug effect: Inhibits bacterial phosphodiesterase (PDE) CdnP activity that responsible for cleaving bacterial c-di-AMP as well as host-derived cGAMP to blunt the host's response to infection.
Max phase: Preclinical (in vitro)
Publication:
Karanja CW, et al., 2021. Identification of a Mycobacterium tuberculosis Cyclic Dinucleotide Phosphodiesterase Inhibitor. ACS Infect Dis 7(2):309-317.