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5-(5-bromo-1H-indol-3-yl)-1H-imidazol-2-amine

Drug details:
Molecular formula: C11H9BrN4

Classification: Indoles; Indoles and derivatives; Organoheterocyclic compounds; Organic compounds;
Chemical structure:
Depiction based on curated SMILES NH 2 N N H Br N H

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits biofilm formation and increases the potency of colistin.
Max phase: Preclinical (in vitro)
Publication:
Huggins WM, et al., 2018. Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria. ACS Med Chem Lett 9(7):702-707.








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