Drug details:
Molecular formula: C₁₁H₁₂ClN₅

Standard name: 3-phenyldiazenylpyridine-2,6-diamine;hydrochloride

Synonyms:

Phenazopyridine HCl Pyridium Urodine Mallophene Pyripyridium Azomine Bisteril Diridone Sedural ......

Curated SMILES: C1=CC=C(C=C1)N=NC2=C(N=C(C=C2)N)N.Cl

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VF: TSST-1 (Toxic shock syndrome toxin-1)
Target: SaeS
Drug effect: Inhibits the kinase activity of SaeS to repress exotoxin production.
Max phase: Preclinical (in vitro)
Publication:
Dufresne K, et al., 2024. Discovery of an antivirulence compound that targets the Staphylococcus aureus SaeRS two-component system to inhibit toxic shock syndrome toxin-1 production. J Biol Chem 300(7):107455.