Drug details:
Molecular formula: C₁₇H₁₄N₄O₂S

Standard name: 5-methyl-4-[(4-nitrophenyl)iminomethyl]-2-phenyl-1H-pyrazole-3-thione

Synonyms:

pyrazolethione, 3 5-methyl-4-[(4-nitrophenyl)iminomethyl]-2-phenyl-1H-pyrazole-3-thione (4e)-5-methyl-4-[[(4-nitrophenyl)amino]methylidene]-2-phenyl-2,4-dihydro-3h-pyrazole-3-thione (4Z)-5-methyl-4-{[(4-nitrophenyl)amino]methylidene}-2-phenyl-2,4-dihydro-3H-pyrazole-3-thione

Curated SMILES: CC1=NN(C2=CC=CC=C2)C(=S)/C1=C/NC1=CC=C([N+](=O)[O-])C=C1

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Others
Target: SrtA
Drug effect: Blocks sortase-catalyzed cleavage and transpeptidation reactions with LPXTG substrate peptides and inhibited the incorporation of surface proteins into the staphylococcal envelope.
Max phase: Preclinical (in vitro)
Publication:
Suree N, et al., 2009. Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors. Bioorg Med Chem 17(20):7174-85.