Drug details:
Molecular formula: C₂₀H₂₂N₂O₄S

Standard name: methyl 5-[methyl-[(E)-3-thiophen-2-ylprop-2-enoyl]amino]-2-morpholin-4-ylbenzoate

Curated SMILES: CN(C1=CC(=C(C=C1)N2CCOCC2)C(=O)OC)C(=O)/C=C/C3=CC=CS3

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Others
Target: SrtA
Drug effect: Blocks sortase-catalyzed cleavage and transpeptidation reactions with LPXTG substrate peptides and inhibited the incorporation of surface proteins into the staphylococcal envelope.
Max phase: Preclinical (in vitro)
Publication:
Chenna BC, et al., 2010. Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors. Eur J Med Chem 45(9):3752-61.