Drug details:
Molecular formula: C₂₀H₂₂N₂O₄

Standard name: methyl 5-[[(E)-3-(furan-2-yl)prop-2-enoyl]amino]-2-piperidin-1-ylbenzoate

Curated SMILES: COC(=O)C1=C(C=CC(=C1)NC(=O)/C=C/C2=CC=CO2)N3CCCCC3

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Others
Target: SrtA
Drug effect: Blocks sortase-catalyzed cleavage and transpeptidation reactions with LPXTG substrate peptides and inhibited the incorporation of surface proteins into the staphylococcal envelope.
Max phase: Preclinical (in vitro)
Publication:
Chenna BC, et al., 2010. Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors. Eur J Med Chem 45(9):3752-61.