Drug details:
Molecular formula: C₁₁H₈O₃

Standard name: 5-hydroxy-2-methylnaphthalene-1,4-dione

Synonyms:

5-hydroxy-2-methylnaphthalene-1,4-dione 5-Hydroxy-2-methyl-1,4-naphthoquinone Plumbagine 2-Methyljuglone Plumbaein Plumbagone 5-Hydroxy-2-methyl-1,4-naphthalenedione 1,4-Naphthalenedione, 5-hydroxy-2-methyl- 5-Hydroxy-2-methyl-[1,4]naphthoquinone ......

Curated SMILES: C1=CC=C2C(=C1)C(=CC(=O)C2=O)O

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Others; Biofilm
Target: SrtA
Drug effect: Inhibits biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Nitulescu G, et al., 2019. Discovery of natural naphthoquinones as sortase A inhibitors and potential anti-infective solutions against Staphylococcus aureus. Drug Dev Res 80(8):1136-1145.