Staphylococcus
Related VFcategory: Others; Adherence; Biofilm
Target: SrtA
Drug effect: Inhibits SrtA-mediated adesion and biofilm formation.
Max phase: Preclinical (in vitro)
Publication: Maggio B, et al., 2016. Discovery of a New Class of Sortase A Transpeptidase Inhibitors to Tackle Gram-Positive Pathogens: 2-(2-Phenylhydrazinylidene)alkanoic Acids and Related Derivatives. Molecules 21(2):241.