Drug details:
Molecular formula: C₂₅H₁₈N₂S₂

Standard name: 5-methyl-4-phenyl-2-[4-(2-phenyl-1,3-thiazol-4-yl)phenyl]-1,3-thiazole

Curated SMILES: CC1=C(N=C(S1)C2=CC=C(C=C2)C3=CSC(=N3)C4=CC=CC=C4)C5=CC=CC=C5

Evidence for compound's anti-virulence activity:

Enterococcus
Related VFcategory: Others; Adherence; Biofilm
Target: SrtA
Drug effect: Inhibits SrtA-mediated adesion and biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Oniga SD, et al., 2017. New 2-Phenylthiazoles as Potential Sortase A Inhibitors: Synthesis, Biological Evaluation and Molecular Docking. Molecules 22(11):1827.

Staphylococcus
Related VFcategory: Others; Adherence; Biofilm
Target: SrtA
Drug effect: Inhibits SrtA-mediated adesion and biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Oniga SD, et al., 2017. New 2-Phenylthiazoles as Potential Sortase A Inhibitors: Synthesis, Biological Evaluation and Molecular Docking. Molecules 22(11):1827.