Drug details:
Molecular formula: C₂₅H₁₇N₃O₂S₂

Standard name: 2-hydroxy-5-[2-[4-(2-phenyl-1,3-thiazol-4-yl)phenyl]-1,3-thiazol-4-yl]benzamide

Curated SMILES: NC(=O)C1=CC(C2=CSC(C3=CC=C(C4=CSC(C5=CC=CC=C5)=N4)C=C3)=N2)=CC=C1O

Evidence for compound's anti-virulence activity:

Enterococcus
Related VFcategory: Others; Adherence; Biofilm
Target: SrtA
Drug effect: Inhibits SrtA-mediated adesion and biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Oniga SD, et al., 2017. New 2-Phenylthiazoles as Potential Sortase A Inhibitors: Synthesis, Biological Evaluation and Molecular Docking. Molecules 22(11):1827.

Staphylococcus
Related VFcategory: Others; Adherence; Biofilm
Target: SrtA
Drug effect: Inhibits SrtA-mediated adesion and biofilm formation.
Max phase: Preclinical (in vitro)
Publication:
Oniga SD, et al., 2017. New 2-Phenylthiazoles as Potential Sortase A Inhibitors: Synthesis, Biological Evaluation and Molecular Docking. Molecules 22(11):1827.