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Compound category: Diazines
(total 6 related compounds in database)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
ML346 Depiction based on curated SMILES O HN O N H O CH 3 O Streptococcus Adherence Preclinical (in vivo) Guan XN, et al. 2022. RSC Med Chem
Lapatinib Depiction based on curated SMILES O N NH F Cl S O O N H CH 3 O N Streptococcus Adherence Preclinical (in vivo) Manzer HS, et al. 2022. PLoS Pathog
(5E)-5-({4-[(2,4-DICHLOROPHENYL)METHOXY]-3-ETHOXYPHENYL}METHYLIDENE)-1-(3,5-DIMETHYLPHENYL)-1,3-DIAZINANE-2,4,6-TRIONE Depiction based on curated SMILES H 3 C CH 3 O O Cl Cl O CH 3 O NH O N Clostridium
Streptococcus		 theta-toxin/PFO (Perfringolysin O)
Pneumolysin		 Preclinical (in vitro)
Preclinical (in vitro)		 Aziz UBA, et al. 2024. Nat Commun
(5E)-5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-1-(3,5-dimethylphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione Depiction based on curated SMILES CH 3 O N H O Cl Cl O CH 3 O N Clostridium
Streptococcus		 theta-toxin/PFO (Perfringolysin O)
Pneumolysin		 Preclinical (in vitro)
Preclinical (in vitro)		 Aziz UBA, et al. 2024. Nat Commun
5-{3-[(2,4-difluorophenoxy)methyl]-4-methoxybenzylidene}-2,4,6(1H,3H,5H)-pyrimidinetrione Depiction based on curated SMILES O F F O O N H CH 3 HN O O Clostridium
Streptococcus		 theta-toxin/PFO (Perfringolysin O)
Pneumolysin		 Preclinical (in vitro)
Preclinical (in vitro)		 Aziz UBA, et al. 2024. Nat Commun
5-{4-[(2,4-dichlorobenzyl)oxy]-3-ethoxybenzylidene}pyrimidine-2,4,6(1H,3H,5H)-trione Depiction based on curated SMILES Cl Cl O O NH O H 3 C HN O O Clostridium
Streptococcus		 theta-toxin/PFO (Perfringolysin O)
Pneumolysin		 Preclinical (in vitro)
Preclinical (in vitro)		 Aziz UBA, et al. 2024. Nat Commun
   
   
   
   
   
   
   
   
   


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