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Compound category: Quinolines and derivatives
(total 23 related compounds in database, current show from 11 to 20)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
7-[morpholin-4-yl(pyridin-3-yl)methyl]quinolin-8-ol Depiction based on curated SMILES O N N OH N Burkholderia Quorum-sensing Preclinical (in vitro) Christensen QH, et al. 2013. Proc Natl Acad Sci U S A
5-nitro-7-[(3-phenylpyrrolidin-1-yl)methyl]quinolin-8-ol Depiction based on curated SMILES N OH O N _ O + N Chlamydia
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Enquist PA, et al. 2012. Bioorg Med Chem Lett
5-nitro-7-[(4-phenyl-1-piperazinyl)methyl]-8-quinolinol Depiction based on curated SMILES N OH O N N _ O + N Chlamydia
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Enquist PA, et al. 2012. Bioorg Med Chem Lett
7-[[4-(4-fluorophenyl)piperazin-1-yl]methyl]-5-nitroquinolin-8-ol Depiction based on curated SMILES N OH F O N N _ O + N Chlamydia
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Enquist PA, et al. 2012. Bioorg Med Chem Lett
7,7-dimethyl-10-(1-naphthyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione Depiction based on curated SMILES H 3 C O O H 3 C HN Clostridium TcdB (Toxin B) Preclinical (in vitro) Farrow MA, et al. 2020. ACS Chem Biol
Propyl 4-(3-bromophenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate Depiction based on curated SMILES O Br CH 3 CH 3 CH 3 NH CH 3 O O Clostridium TcdB (Toxin B) Preclinical (in vitro) Farrow MA, et al. 2020. ACS Chem Biol
2-[4-[3-(furan-2-yl)-5-phenyl-1,2-oxazol-4-yl]phenyl]quinoline-4-carboxylic acid Depiction based on curated SMILES O N O N HO O Escherichia
Salmonella		 TTSS (Type III secretion system)
TTSS (SPI-2 encode)		 Preclinical (in vitro)
Preclinical (in vitro)		 El Qaidi S, et al. 2018. Front Cell Infect Microbiol
N-(4-amino-2-methyl-6-quinolinyl)-N-{2-[(4-amino-2-methyl-6-quinolinyl)amino]-6-methyl-4-pyrimidinyl}amine Depiction based on curated SMILES N NH N CH 3 NH 2 N CH 3 NH 2 H 3 C N N H Salmonella TTSS (SPI-1 encode) Preclinical (in vitro) von Ambüren J, et al. 2020. Microorganisms
1'-butyl-4'-(nitromethyl)-1',4'-dihydro-2,3'-biquinoline Depiction based on curated SMILES _ O O + N H 3 C N N Shigella VirF Preclinical (in vitro) Koppolu V, et al. 2013. Infect Immun
4-Aminoquinaldine Depiction based on curated SMILES CH 3 NH 2 N Shigella TTSS (Type III secretion system) Preclinical (in vitro) Dey S, et al. 2017. ChemMedChem
   


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