Drug details:
Molecular formula: C₁₅H₁₇NO₄

Standard name: 3-(6,6-dimethyl-3-oxooxan-2-yl)-3-hydroxy-1H-indol-2-one

Synonyms:

3-(6,6-Dimethyl-3-oxotetrahydro-2H-pyran-2-yl)-3-hydroxyindolin-2-one 3-(6,6-dimethyl-3-oxooxan-2-yl)-3-hydroxy-1H-indol-2-one

Curated SMILES: CC1(C)CCC(=O)C(C2(O)C(=O)NC3=CC=CC=C32)O1

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits a series of virulence factors such as quorum sensing, swarming and synthesis of pyocyanin, pyochelin and pyoverdine.
Max phase: Preclinical (in vitro)
Publication:
von Ambüren J, et al., 2020. Comprehensive Host Cell-Based Screening Assays for Identification of Anti-Virulence Drugs Targeting Pseudomonas aeruginosa and Salmonella Typhimurium. Microorganisms 8(8):1096.