Drug details:
Molecular formula: C₁₅H₁₂N₂O₃

Standard name: 3-hydroxy-3-(2-oxo-2-pyridin-4-ylethyl)-1H-indol-2-one

Synonyms:

3-hydroxy-3-(2-oxo-2-pyridin-4-ylethyl)-1H-indol-2-one 2H-Indol-2-one, 1,3-dihydro-3-hydroxy-3-[2-oxo-2-(4-pyridinyl)ethyl]- 3-hydroxy-3-[2-oxo-2-(4-pyridyl)ethyl]indolin-2-one

Curated SMILES: C1=CC=C2C(=C1)C(C(=O)N2)(CC(=O)C3=CC=NC=C3)O

Evidence for compound's anti-virulence activity:

Pseudomonas
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits a series of virulence factors such as quorum sensing, swarming and synthesis of pyocyanin, pyochelin and pyoverdine.
Max phase: Preclinical (in vitro)
Publication:
von Ambüren J, et al., 2020. Comprehensive Host Cell-Based Screening Assays for Identification of Anti-Virulence Drugs Targeting Pseudomonas aeruginosa and Salmonella Typhimurium. Microorganisms 8(8):1096.