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N'-(2-Hydroxy-3,5-dibromobenzylidene)-4-nitrobenzhydrazide

Drug details:
Molecular formula: C14H9Br2N3O4

Classification: Nitrobenzenes; Benzene and substituted derivatives; Benzenoids; Organic compounds;
Synonyms:  n'-(3,5-dibromo-2-hydroxybenzylidene)-4-nitrobenzohydrazide
N-[(3,5-Dibromo-2-hydroxyphenyl)methylideneamino]-4-nitrobenzamide

Chemical structure:
Depiction based on curated SMILES Br _ O O + N OH O Br N HN

Evidence for compound's anti-virulence activity:

Chlamydia
Related VF: TTSS (Type III secretion system)
Target: Not determined
Drug effect: Inhibits T3SS activity and disrupts progression of the chlaymdial development cycle.
Max phase: Preclinical (in vitro)
Publication:
Wolf K, et al., 2006. Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycle. Mol Microbiol 61(6):1543-55.








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