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Compound category: Nitrobenzenes
(total 9 related compounds in database)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
6-[(4-nitrobenzoyl)amino]hexanoic Acid Depiction based on curated SMILES O _ O O + N O HN OH Yersinia TTSS secreted effectors Preclinical (in vivo) Liang F, et al. 2003. J Biol Chem
3-hydroxy-N-[(Z)-[5-(2-nitrophenyl)furan-2-yl]methylideneamino]benzamide Depiction based on curated SMILES NH _ O O + N OH O N O Brucella VirB type IV secretion system Preclinical (in vivo) Smith MA, et al. 2012. Chem Biol
N-[[amino(pyridin-2-yl)methylidene]amino]-5-methyl-2-nitrobenzamide Depiction based on curated SMILES N H N NH N H CH 3 O _ O O + N Brucella VirB type IV secretion system Preclinical (in vivo) Paschos A, et al. 2011. Infect Immun
N'-(2-Hydroxy-3,5-dibromobenzylidene)-4-nitrobenzhydrazide Depiction based on curated SMILES Br _ O O + N OH O Br N HN Chlamydia TTSS (Type III secretion system) Preclinical (in vitro) Wolf K, et al. 2006. Mol Microbiol
N-[(E)-(3-fluoro-2-hydroxyphenyl)methylideneamino]-4-nitrobenzamide Depiction based on curated SMILES _ O O + N OH O F N N H Chlamydia TTSS (Type III secretion system) Preclinical (in vitro) Dahlgren MK, et al. 2010. Bioorg Med Chem
2-[4-(2-Phenyl-4-thiazolyl)phenyl]-4-(4-nitrophenyl)thiazole Depiction based on curated SMILES _ O O + N S N S N Enterococcus
Staphylococcus		 Others; Adherence; Biofilm
Others; Adherence; Biofilm		 Preclinical (in vitro)
Preclinical (in vitro)		 Oniga SD, et al. 2017. Molecules
N'-[(E)-(2,4-dihydroxyphenyl)methylidene]-4-nitrobenzohydrazide Depiction based on curated SMILES _ O O + N O HO OH N N H Escherichia TTSS (Type III secretion system) Preclinical (in vitro) Tree JJ, et al. 2009. Infect Immun; Wang D, et al. 2011. J Biol Chem
2-((5E)-5-{[5-(3-NITROPHENYL)-2-FURYL]METHYLENE}-4-OXO-2-THIOXO-1,3-THIAZOLIDIN-3-YL)ETHANESULFONIC ACID Depiction based on curated SMILES OH O O S S S N O O _ O O + N Mycobacterium Exoenzyme Preclinical (in vitro) Mori M, et al. 2014. Bioorg Med Chem Lett
N'-(3,5-Dibromosalicylidene)-4-nitrobenzhydrazide Depiction based on curated SMILES Br _ O O + N HO O Br N N H Salmonella
Yersinia		 TTSS (SPI-1 encode); TTSS (SPI-2 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Negrea A, et al. 2007. Antimicrob Agents Chemother
Kauppi AM, et al. 2003. Chem Biol; Nordfelth R, et al. 2005. Infect Immun
   
   
   


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