Drug details:
Molecular formula: C₁₄H₁₁N₃O₅

Standard name: N-[(E)-(2,4-dihydroxyphenyl)methylideneamino]-4-nitrobenzamide

Synonyms:

N'-(2,4-dihydroxybenzylidene)-4-nitrobenzohydrazide (E)-N'-(2,4-Dihydroxybenzylidene)-4-nitrobenzohydrazide N-[(E)-(2,4-dihydroxyphenyl)methyleneamino]-4-nitro-benzamide

Curated SMILES: O=C(N/N=C/C1=C(O)C=C(O)C=C1)C1=CC=C([N+](=O)[O-])C=C1

Evidence for compound's anti-virulence activity:

Escherichia
Related VF: TTSS (Type III secretion system)
Target: WrbA;Tpx;FolX
Drug effect: Global effects on virulence gene regulation and effectively reduce formation of actin pedestals in vitro.
Max phase: Preclinical (in vitro)
Publications:
Tree JJ, et al., 2009. Characterization of the effects of salicylidene acylhydrazide compounds on type III secretion in Escherichia coli O157:H7. Infect Immun 77(10):4209-20.
Wang D, et al., 2011. Identification of bacterial target proteins for the salicylidene acylhydrazide class of virulence-blocking compounds. J Biol Chem 286(34):29922-31.