Drug details:
Classification: N-alkylindoles; Indoles and derivatives; Organoheterocyclic compounds; Organic compounds;

Curated SMILES: CCCCN1C=CC2=CC=CC(CCC(=O)O)=C21

Evidence for compound's anti-virulence activity:

Vibrio
Related VF: TCP (Toxin-coregulated pilus)
Target: TcpN/ToxT
Drug effect: Inhibits ToxT, an AraC family regulator that binds the tcpA and ctx promoters and directly activates virulence gene expression.
Max phase: Preclinical (in vivo)
Publication:
Woodbrey AK, et al., 2018. A Modified ToxT Inhibitor Reduces Vibrio cholerae Virulence in Vivo. Biochemistry 57(38):5609-5615.