|
Compound 8
(internal name in literature) |
|
Vibrio |
TCP (Toxin-coregulated pilus) |
Preclinical (in vivo) |
Woodbrey AK, et al. 2018. Biochemistry |
|
| 4-(5-bromo-1-butylindol-3-yl)pyrimidin-2-amine |
|
Staphylococcus |
Biofilm |
Preclinical (in vitro) |
Huggins WM, et al. 2018. ACS Med Chem Lett |
|
| 4-(5-bromo-1-ethylindol-3-yl)pyrimidin-2-amine |
|
Staphylococcus |
Biofilm |
Preclinical (in vitro) |
Huggins WM, et al. 2018. ACS Med Chem Lett |
|
| 4-(5-bromo-1-propylindol-3-yl)pyrimidin-2-amine |
|
Staphylococcus |
Biofilm |
Preclinical (in vitro) |
Huggins WM, et al. 2018. ACS Med Chem Lett |
|
| 4-(6-bromo-1-ethylindol-3-yl)pyrimidin-2-amine |
|
Staphylococcus |
Biofilm |
Preclinical (in vitro) |
Huggins WM, et al. 2018. ACS Med Chem Lett |
|
| 4-(6-bromo-1-methylindol-3-yl)pyrimidin-2-amine |
|
Staphylococcus |
Biofilm |
Preclinical (in vitro) |
Huggins WM, et al. 2018. ACS Med Chem Lett |
|
| 4-(6-bromo-1-propylindol-3-yl)pyrimidin-2-amine |
|
Staphylococcus |
Biofilm |
Preclinical (in vitro) |
Huggins WM, et al. 2018. ACS Med Chem Lett |
|
Compound 7
(internal name in literature) |
|
Vibrio |
TCP (Toxin-coregulated pilus) |
Preclinical (in vitro) |
Woodbrey AK, et al. 2018. Biochemistry |
|
| 5-({1-[(2-chloro-1,3-thiazol-5-yl)methyl]-1H-indol-3-yl}methylene)-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione |
|
Yersinia |
TTSS secreted effectors |
Preclinical (in vitro) |
Hu X, et al. 2013. Bioorg Med Chem Lett |
|
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