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4-(5-bromo-1-propylindol-3-yl)pyrimidin-2-amine

Drug details:
Molecular formula: C15H15BrN4

Classification: N-alkylindoles; Indoles and derivatives; Organoheterocyclic compounds; Organic compounds;
Chemical structure:
Depiction based on curated SMILES Br N NH 2 H 3 C N N

Evidence for compound's anti-virulence activity:

Staphylococcus
Related VFcategory: Biofilm
Target: Not determined
Drug effect: Inhibits biofilm formation and increases the potency of colistin.
Max phase: Preclinical (in vitro)
Publication:
Huggins WM, et al., 2018. Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria. ACS Med Chem Lett 9(7):702-707.








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