Drug details:
Molecular formula: C₉H₈N₄OS

Standard name: 1-phenyl-3-(thiadiazol-5-yl)urea

Synonyms:

Defolit Dropp 1-phenyl-3-(thiadiazol-5-yl)urea Urea, N-phenyl-N'-1,2,3-thiadiazol-5-yl- Caswell No. 659A Thidiauron N-Phenyl-N'-1,2,3-thiadiazol-5-ylurea Thidiazuron [ANSI:BSI:ISO] EINECS 257-356-7 ......

Curated SMILES: O=C(NC1=CC=CC=C1)NC1=CN=NS1

Evidence for compound's anti-virulence activity:

Shigella
Related VF: VirF
Target: VirF
Drug effect: Inhibits transcriptional activator.
Max phase: Preclinical (in vitro)
Publications:
Hurt JK, et al., 2010. High-throughput screening of the virulence regulator VirF: a novel antibacterial target for shigellosis. J Biomol Screen 15(4):379-87.
Emanuele AA, et al., 2014. Potential novel antibiotics from HTS targeting the virulence-regulating transcription factor, VirF, from Shigella flexneri. J Antibiot (Tokyo) 67(5):379-86.
Emanuele AA, et al., 2015. Mechanism of Action and Initial, In Vitro SAR of an Inhibitor of the Shigella flexneri Virulence Regulator VirF. PLoS One 10(9):e0137410.