Drug details:
Molecular formula: C₁₃H₁₁Cl₂N₃O₄S

Standard name: 5-chloro-N-(3-chloro-4-methoxyphenyl)-2-methylsulfonylpyrimidine-4-carboxamide

Curated SMILES: C1=C(OC)C(Cl)=CC(NC(=O)C2N=C(N=CC=2Cl)S(C)(=O)=O)=C1

Evidence for compound's anti-virulence activity:

Shigella
Related VF: VirF
Target: VirF
Drug effect: Inhibits transcriptional activator.
Max phase: Preclinical (in vitro)
Publications:
Emanuele AA, et al., 2014. Potential novel antibiotics from HTS targeting the virulence-regulating transcription factor, VirF, from Shigella flexneri. J Antibiot (Tokyo) 67(5):379-86.
Emanuele AA, et al., 2015. Mechanism of Action and Initial, In Vitro SAR of an Inhibitor of the Shigella flexneri Virulence Regulator VirF. PLoS One 10(9):e0137410.