Drug details:
Molecular formula: C₁₆H₁₂Cl₂N₄O

Standard name: N-[4-(2-amino-1H-imidazol-5-yl)phenyl]-3,5-dichlorobenzamide

Curated SMILES: C1=CC(=CC=C1C2=CN=C(N2)N)NC(=O)C3=CC(=CC(=C3)Cl)Cl

Evidence for compound's anti-virulence activity:

Francisella
Related VFcategory: Regulation
Target: QseB
Drug effect: Binds with high affinity to QseB to hinder its DNA-binding activity thus to impede the initiation of downstream events such as theformation of biofilms, protective responses, and virulence factors.
Max phase: Preclinical (in vitro)
Publication:
Milton ME, et al., 2017. Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds. Mol Microbiol 106(2):223-235.