Drug details:
Molecular formula: C₁₆H₁₃NO₃

Standard name: 4-hydroxy-2-oxo-N,4-diphenylbut-3-enamide

Curated SMILES: O=C(/C=C(\O)C(=O)NC1=CC=CC=C1)C1=CC=CC=C1

Evidence for compound's anti-virulence activity:

Brucella
Related VF: VirB type IV secretion system
Target: VirB8
Drug effect: Inhibits T4SS by targeting an essential assembly protein VirB8.
Max phase: Preclinical (in vivo)
Publication:
Paschos A, et al., 2011. An in vivo high-throughput screening approach targeting the type IV secretion system component VirB8 identified inhibitors of Brucella abortus 2308 proliferation. Infect Immun 79(3):1033-43.