Drug details:
Molecular formula: C₂₀H₂₈N₆O₅

Standard name: N-[2-[4-[(2-acetamidophenoxy)methyl]triazol-1-yl]ethyl]-N'-hydroxy-2-(2-methylpropyl)propanediamide

Curated SMILES: CC(C)CC(C(=O)NCCN1C=C(N=N1)COC2=CC=CC=C2NC(=O)C)C(=O)NO

Evidence for compound's anti-virulence activity:

Bacillus
Related VF: Collagenase
Target: ColQ1;ColA
Drug effect: Binds to bacterial collagenase to inhibit their activity thus to maintain the cell attachment, cell morphology, and cell viability.
Max phase: Preclinical (in vitro)
Publication:
Alhayek A, et al., 2022. Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases. J Med Chem 65(19):12933-12955.

Clostridium
Related VF: Collagenase
Target: ColG;ColH
Drug effect: Binds to bacterial collagenase to inhibit their activity thus to maintain the cell attachment, cell morphology, and cell viability.
Max phase: Preclinical (in vitro)
Publication:
Alhayek A, et al., 2022. Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases. J Med Chem 65(19):12933-12955.