Drug details:
Molecular formula: C₁₄H₁₀ClF₃N₂O

Standard name: 1-(4-chlorophenyl)-3-[3-(trifluoromethyl)phenyl]urea

Synonyms:

1-(4-Chloro-phenyl)-3-(3-trifluoromethyl-phenyl)-urea 1-(4-CHLOROPHENYL)-3-(3-TRIFLUOROMETHYLPHENYL)UREA N-(4-CHLOROPHENYL)-N'-[3-(TRIFLUOROMETHYL)PHENYL]UREA

Curated SMILES: C1=CC(=CC(=C1)NC(=O)NC2=CC=C(C=C2)Cl)C(F)(F)F

Evidence for compound's anti-virulence activity:

Bacillus
Related VFcategory: Nutritional/Metabolic factor
Target: KtrAB
Drug effect: Inhibits KtrAB ion channel complex, a component of the K+ homeostasis machinery to interfere with pathogen survival in host cells.
Max phase: Preclinical (in vitro)
Publication:
Fernandes AS, et al., 2021. Fluorometric Liposome Screen for Inhibitors of a Physiologically Important Bacterial Ion Channel. Front Microbiol 12:603700.