Drug details:
Molecular formula: C₁₆H₉BrF₈NO₄P

Standard name: [[4-[[4-bromo-3,5-bis(trifluoromethyl)phenyl]carbamoyl]phenyl]-difluoromethyl]phosphonic acid

Synonym:

[[4-[[4-bromo-3,5-bis(trifluoromethyl)phenyl]carbamoyl]phenyl]-difluoro-methyl]phosphonic acid

Curated SMILES: C1=CC(=CC=C1C(=O)NC2=CC(=C(C(=C2)C(F)(F)F)Br)C(F)(F)F)C(F)(F)P(=O)(O)O

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpA
Drug effect: Inhibits protein tyrosine phosphatase PtpA to disrupt phagosome acidification and maturation.
Max phase: Preclinical (in vitro)
Publication:
Rawls KA, et al., 2009. Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Bioorg Med Chem Lett 19(24):6851-4.