Drug details:
Molecular formula: C₂₃H₁₉F₄NO₃

Standard name: 5-[2-cyclohexyl-4-[4-fluoro-3-(trifluoromethyl)phenyl]phenyl]-1,2-oxazole-3-carboxylic acid

Synonyms:

3-Isoxazolecarboxylic acid, 5-[3-cyclohexyl-4'-fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]- 5-{2-cyclohexyl-4-[4-fluoro-3-(trifluoromethyl)phenyl]phenyl}-1,2-oxazole-3-carboxylic acid

Curated SMILES: C1CCC(CC1)C2=C(C=CC(=C2)C3=CC(=C(C=C3)F)C(F)(F)F)C4=CC(=NO4)C(=O)O

Evidence for compound's anti-virulence activity:

Mycobacterium
Related VFcategory: Exoenzyme
Target: PtpB
Drug effect: Inhibits protein tyrosine phosphatase B (PtpB) to interfere with signal transduction pathways in macrophages.
Max phase: Preclinical (in vitro)
Publication:
Soellner MB, et al., 2007. Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB. J Am Chem Soc 129(31):9613-5.