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Compound category: Indoles and derivatives
(total 6 related compounds in database)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
(S)-(-)-Indoline-2-carboxylic acid Depiction based on curated SMILES N H O OH Yersinia TTSS secreted effectors Preclinical (in vivo) Liang F, et al. 2003. J Biol Chem
[1-(1H-indol-3-yl)-1-oxopropan-2-yl] 2-(4-acetamidophenyl)-1,3-dioxoisoindole-5-carboxylate Depiction based on curated SMILES CH 3 O N H O O N H N CH 3 O O O Burkholderia
Yersinia		 Bsa T3SS
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vivo)		 Swietnicki W, et al. 2011. PLoS One
1-[(5Z)-5-(1-butyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide Depiction based on curated SMILES O N O H 2 N H 3 C N S O N Yersinia TTSS secreted effectors Preclinical (in vitro) Hu X, et al. 2013. Bioorg Med Chem Lett
1H-Indole, 3-(2-pyridin-4-yl-thiazol-4-yl)- Depiction based on curated SMILES N N S HN Pseudomonas
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Harmon DE, et al. 2010. Antimicrob Agents Chemother
4-[1,3-dioxo-5-(4-oxo-4H-3,1-benzoxazin-2-yl)-1,3-dihydro-2H-isoindol-2-yl]benzoic acid Depiction based on curated SMILES OH O O N O N O O Yersinia TTSS secreted effectors Preclinical (in vitro) Hu X, et al. 2013. Bioorg Med Chem Lett
5-({1-[(2-chloro-1,3-thiazol-5-yl)methyl]-1H-indol-3-yl}methylene)-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione Depiction based on curated SMILES Cl O CH 3 N O S H 3 C N N O N Yersinia TTSS secreted effectors Preclinical (in vitro) Hu X, et al. 2013. Bioorg Med Chem Lett
   
   
   
   
   
   
   
   
   


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