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Compound category: Azoles
(total 48 related compounds in database, current show from 11 to 20)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
(5R,6R)-5,6-bis[[4-(cyclopentylmethyl)triazol-1-yl]methyl]-4,5,6,7-tetrahydro-1H-benzimidazol-2-amine Depiction based on curated SMILES N H N N N N NH N N H NH 2 Acinetobacter
Pseudomonas		 Biofilm
Biofilm		 Preclinical (in vitro)
Preclinical (in vitro)		 Huigens RW 3rd, et al. 2009. Org Biomol Chem
(5R,6R)-5,6-bis[[4-(phenoxymethyl)triazol-1-yl]methyl]-4,5,6,7-tetrahydro-1H-benzimidazol-2-amine Depiction based on curated SMILES O N N H N N N N HN N H NH 2 O Acinetobacter
Pseudomonas		 Biofilm
Biofilm		 Preclinical (in vitro)
Preclinical (in vitro)		 Huigens RW 3rd, et al. 2009. Org Biomol Chem
(E)-3-(4-Acetyl-phenyl)-N-[4-(1-hydroxy-6-nitro-1H-benzoimidazol-2-yl)-phenyl]-acrylamide Depiction based on curated SMILES N + N O _ O N HO H 3 C N H O O Pseudomonas TTSS (Type III secretion system) Preclinical (in vitro) Marsden AE, et al. 2016. Antimicrob Agents Chemother
(E)-3-(4-acetylphenyl)-N-(4-(6-cyano-1-hydroxy-1H-benzo[d]imidazol-2-yl)phenyl)acrylamide Depiction based on curated SMILES HO N N N H 3 C N H O O Pseudomonas TTSS (Type III secretion system) Preclinical (in vitro) Marsden AE, et al. 2016. Antimicrob Agents Chemother
(E)-3-(4-fluorophenyl)-N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]prop-2-enamide Depiction based on curated SMILES HO N _ O O + N N O N H F Pseudomonas
Yersinia
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)
Preclinical (in vivo)		 Marsden AE, et al. 2016. Antimicrob Agents Chemother
Kim OK, et al. 2009. J Med Chem
Garrity-Ryan LK, et al. 2010. Infect Immun
1-{(E)-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)imino]methyl}naphthalen-2-ol Depiction based on curated SMILES N OH H 3 C CH 3 N N Pseudomonas
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Harmon DE, et al. 2010. Antimicrob Agents Chemother
2,2,2-trifluoro-N-[2-[2-(4-iodoanilino)-2-oxoethyl]sulfanyl-3H-benzimidazol-5-yl]acetamide Depiction based on curated SMILES F I NH N H F O F O HN N S Pseudomonas Biofilm Preclinical (in vitro) Starkey M, et al. 2014. PLoS Pathog
2-(1,3-benzoxazol-2-ylsulfanyl)-N-phenylacetamide Depiction based on curated SMILES NH O O N S Pseudomonas Biofilm Preclinical (in vitro) Starkey M, et al. 2014. PLoS Pathog
2-(1H-benzimidazol-2-ylsulfanyl)-N-(3,4-dichlorophenyl)acetamide Depiction based on curated SMILES Cl Cl NH N H O N S Pseudomonas Biofilm Preclinical (in vitro) Starkey M, et al. 2014. PLoS Pathog
2-(1H-benzimidazol-2-ylthio)-N-[3-(methylthio)phenyl]acetamide Depiction based on curated SMILES S N H N CH 3 O N H S Pseudomonas Biofilm Preclinical (in vitro) Starkey M, et al. 2014. PLoS Pathog
   


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