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Compound category: Benzene and substituted derivatives
(total 17 related compounds in database, current show from 1 to 10)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
Fluorothiazinon Depiction based on curated SMILES OH O S F F H 3 C NH O N N O Acinetobacter
Chlamydia
Klebsiella
Pseudomonas
Salmonella		 Biofilm
TTSS (Type III secretion system)
Biofilm
TTSS (Type III secretion system)
TTSS (SPI-1 encode); TTSS (SPI-2 encode)		 Preclinical (in vivo)
Preclinical (in vivo)
Preclinical (in vitro)
Preclinical (in vivo)
Phase II trial		 Bondareva NE, et al. 2022. J Antibiot (Tokyo)
Zigangirova NA, et al. 2012. Acta Naturae; Koroleva EA, et al. 2015. Biomed Res Int; Zigangirova NA, et al. 2016. J Med Microbiol
Tsarenko SV, et al. 2023. J Antibiot (Tokyo)
Sheremet AB, et al. 2018. Biomed Res Int
Nesterenko LN, et al. 2016. J Antibiot (Tokyo); Zigangirova NA, et al. 2021. J Antibiot (Tokyo)
4-[(3-ethoxy-2-hydroxyphenyl)methyl]-N-(4-fluorophenyl)-5-oxo-1,3,4-thiadiazine-2-carboxamide Depiction based on curated SMILES O S F H 3 C NH O N N OH O Chlamydia TTSS (Type III secretion system) Preclinical (in vitro) Zigangirova NA, et al. 2012. Acta Naturae
N'-(2-Hydroxy-3,5-dibromobenzylidene)-4-nitrobenzhydrazide Depiction based on curated SMILES Br _ O O + N OH O Br N HN Chlamydia TTSS (Type III secretion system) Preclinical (in vitro) Wolf K, et al. 2006. Mol Microbiol
N-[(E)-(3-fluoro-2-hydroxyphenyl)methylideneamino]-4-nitrobenzamide Depiction based on curated SMILES _ O O + N OH O F N N H Chlamydia TTSS (Type III secretion system) Preclinical (in vitro) Dahlgren MK, et al. 2010. Bioorg Med Chem
N'-[(E)-(5-bromo-2-hydroxyphenyl)methylidene]-2-phenylacetohydrazide Depiction based on curated SMILES N OH Br O N H Chlamydia TTSS (Type III secretion system) Preclinical (in vitro) Dahlgren MK, et al. 2010. Bioorg Med Chem
(E)-N'-(5-Bromo-2-hydroxybenzylidene)-3-methoxybenzohydrazide Depiction based on curated SMILES OH Br H 3 C N N H O O Chlamydia TTSS (Type III secretion system) Preclinical (in vitro) Dahlgren MK, et al. 2010. Bioorg Med Chem
N-[(E)-(5-tert-butyl-2-hydroxyphenyl)methylideneamino]-4-methylbenzamide Depiction based on curated SMILES OH CH 3 H 3 C H 3 C CH 3 N N H O Chlamydia TTSS (Type III secretion system) Preclinical (in vitro) Dahlgren MK, et al. 2010. Bioorg Med Chem
Compound 17
(internal name in literature)		 Depiction based on curated SMILES O S F F F CH 3 HN O N N OH O Chlamydia TTSS (Type III secretion system) Preclinical (in vitro) Zigangirova NA, et al. 2012. Acta Naturae
Compound 18
(internal name in literature)		 Depiction based on curated SMILES N S O OH Br N O F F F N H Chlamydia TTSS (Type III secretion system) Preclinical (in vitro) Zigangirova NA, et al. 2012. Acta Naturae
Compound 19
(internal name in literature)		 Depiction based on curated SMILES O S F F F H 3 C NH O N N OH O Chlamydia TTSS (Type III secretion system) Preclinical (in vitro) Zigangirova NA, et al. 2012. Acta Naturae
   


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