|
2-[(5-nitro-1H-benzimidazol-2-yl)sulfanyl]-N-(4-phenoxyphenyl)acetamide |
|
Pseudomonas |
Biofilm |
Preclinical (in vivo) |
Starkey M, et al. 2014. PLoS Pathog |
|
Fluorothiazinon |
Depiction based on curated SMILES
OH
O
S
F
F
H
3
C
NH
O
N
N
O
|
Acinetobacter Chlamydia Klebsiella Pseudomonas Salmonella |
Biofilm TTSS (Type III secretion system) Biofilm TTSS (Type III secretion system) TTSS (SPI-1 encode); TTSS (SPI-2 encode) |
Preclinical (in vivo) Preclinical (in vivo) Preclinical (in vitro) Preclinical (in vivo) Phase II trial |
Bondareva NE, et al. 2022. J Antibiot (Tokyo) Zigangirova NA, et al. 2012. Acta Naturae; Koroleva EA, et al. 2015. Biomed Res Int; Zigangirova NA, et al. 2016. J Med Microbiol Tsarenko SV, et al. 2023. J Antibiot (Tokyo) Sheremet AB, et al. 2018. Biomed Res Int Nesterenko LN, et al. 2016. J Antibiot (Tokyo); Zigangirova NA, et al. 2021. J Antibiot (Tokyo) |
|
N-(4-cyanophenyl)-2-fluoro-N'-(4-phenoxyphenyl)propanediamide |
Depiction based on curated SMILES
O
N
N
H
O
F
O
HN
|
Pseudomonas |
Biofilm |
Preclinical (in vivo) |
Singh VK, et al. 2022. Nat Commun |
|
ML364 |
Depiction based on curated SMILES
S
F
F
F
S
O
O
HN
H
3
C
O
N
H
N
|
Klebsiella Pseudomonas Staphylococcus |
Biofilm; Biofilm Pyocyanin Biofilm |
Preclinical (in vivo) Preclinical (in vivo) Preclinical (in vivo) |
Zhang Y, et al. 2022. Front Microbiol
|
|
2-fluoro-N-(4-phenoxyphenyl)-N'-[4-(trifluoromethyl)phenyl]propanediamide |
Depiction based on curated SMILES
O
F
F
F
F
NH
O
N
H
O
|
Pseudomonas |
Biofilm |
Preclinical (in vitro) |
Singh VK, et al. 2022. Nat Commun |
|
3-(2-amino-1H-imidazol-5-yl)-N-(4-phenylbutyl)propanamide;hydrochloride |
Depiction based on curated SMILES
ClH
NH
2
HN
N
O
NH
|
Pseudomonas |
Biofilm |
Preclinical (in vitro) |
Ballard TE, et al. 2008. Chemistry |
|
3-(2-amino-1H-imidazol-5-yl)-N-[2-(4-bromophenyl)ethyl]propanamide;hydrochloride |
Depiction based on curated SMILES
O
ClH
Br
NH
2
HN
N
NH
|
Pseudomonas |
Biofilm |
Preclinical (in vitro) |
Ballard TE, et al. 2008. Chemistry |
|
N'-(3-chloro-4-cyanophenyl)-N-(4-cyanophenyl)propanediamide |
Depiction based on curated SMILES
N
H
Cl
N
N
O
O
HN
|
Pseudomonas |
Biofilm |
Preclinical (in vitro) |
Singh VK, et al. 2022. Nat Commun |
|
N'-(4-bromophenyl)-N-(4-cyanophenyl)propanediamide |
Depiction based on curated SMILES
O
Br
N
H
N
O
NH
|
Pseudomonas |
Biofilm |
Preclinical (in vitro) |
Singh VK, et al. 2022. Nat Commun |
|
N'-(4-chlorophenyl)-N-(4-cyanophenyl)propanediamide |
Depiction based on curated SMILES
O
Cl
N
H
N
O
NH
|
Pseudomonas |
Biofilm |
Preclinical (in vitro) |
Singh VK, et al. 2022. Nat Commun |
|
| | |