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Compound category: Benzene and substituted derivatives
(total 12 related compounds in database, current show from 1 to 10)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
Fluorothiazinon Depiction based on curated SMILES OH O S F F H 3 C NH O N N O Acinetobacter
Chlamydia
Klebsiella
Pseudomonas
Salmonella		 Biofilm
TTSS (Type III secretion system)
Biofilm
TTSS (Type III secretion system)
TTSS (SPI-1 encode); TTSS (SPI-2 encode)		 Preclinical (in vivo)
Preclinical (in vivo)
Preclinical (in vitro)
Preclinical (in vivo)
Phase II trial		 Bondareva NE, et al. 2022. J Antibiot (Tokyo)
Zigangirova NA, et al. 2012. Acta Naturae; Koroleva EA, et al. 2015. Biomed Res Int; Zigangirova NA, et al. 2016. J Med Microbiol
Tsarenko SV, et al. 2023. J Antibiot (Tokyo)
Sheremet AB, et al. 2018. Biomed Res Int
Nesterenko LN, et al. 2016. J Antibiot (Tokyo); Zigangirova NA, et al. 2021. J Antibiot (Tokyo)
1-phenyl-3-[4-(phenylsulfamoyl)phenyl]thiourea Depiction based on curated SMILES NH S N H O HN O S Escherichia
Salmonella		 Regulation
QseBC		 Preclinical (in vivo)
Preclinical (in vivo)		 Rasko DA, et al. 2008. Science
({1-[2-(2-fluorophenyl)ethyl]-4-piperidinyl}methyl)methyl(3-thienylmethyl)amine Depiction based on curated SMILES S F CH 3 N N Salmonella Biofilm Preclinical (in vivo) Woolard KJ, et al. 2022. Eur J Med Chem
Compound 7b
(internal name in literature)		 Depiction based on curated SMILES N Cl Cl CH 3 S N Salmonella Biofilm Preclinical (in vivo) Woolard KJ, et al. 2022. Eur J Med Chem
Compound 7d
(internal name in literature)		 Depiction based on curated SMILES N Br Br CH 3 S N Salmonella Biofilm Preclinical (in vivo) Woolard KJ, et al. 2022. Eur J Med Chem
Compound 8j
(internal name in literature)		 Depiction based on curated SMILES CH 3 N S N Salmonella Biofilm Preclinical (in vivo) Woolard KJ, et al. 2022. Eur J Med Chem
Propofol Depiction based on curated SMILES CH 3 H 3 C CH 3 CH 3 OH Salmonella Invasion Preclinical (in vitro) Ridge Y, et al. 2018. J Appl Microbiol
Mefenamic acid Depiction based on curated SMILES H 3 C HO O CH 3 N H Salmonella Invasion Preclinical (in vitro) Ridge Y, et al. 2018. J Appl Microbiol
3,4-DIMETHYLBENZOIC ACID Depiction based on curated SMILES CH 3 O HO CH 3 Salmonella TTSS (SPI-1 encode) Preclinical (in vitro) Peixoto RJM, et al. 2017. Appl Environ Microbiol
(E)-N'-(2,3,4-Trihydroxybenzylidene)benzohydrazide Depiction based on curated SMILES OH OH O HO N N H Escherichia
Salmonella		 TTSS (Type III secretion system)
TTSS (SPI-1 encode); TTSS (SPI-2 encode)		 Preclinical (in vitro)
Preclinical (in vitro)		 Tree JJ, et al. 2009. Infect Immun; Wang D, et al. 2011. J Biol Chem
Negrea A, et al. 2007. Antimicrob Agents Chemother
   


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