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Compound category: Benzenoids
(total 21 related compounds in database, current show from 1 to 10)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
2-[(5-nitro-1H-benzimidazol-2-yl)sulfanyl]-N-(4-phenoxyphenyl)acetamide Depiction based on curated SMILES NH O NH O _ O O + N N S Pseudomonas Biofilm Preclinical (in vivo) Starkey M, et al. 2014. PLoS Pathog
Fluorothiazinon Depiction based on curated SMILES OH O S F F H 3 C NH O N N O Acinetobacter
Chlamydia
Klebsiella
Pseudomonas
Salmonella		 Biofilm
TTSS (Type III secretion system)
Biofilm
TTSS (Type III secretion system)
TTSS (SPI-1 encode); TTSS (SPI-2 encode)		 Preclinical (in vivo)
Preclinical (in vivo)
Preclinical (in vitro)
Preclinical (in vivo)
Phase II trial		 Bondareva NE, et al. 2022. J Antibiot (Tokyo)
Zigangirova NA, et al. 2012. Acta Naturae; Koroleva EA, et al. 2015. Biomed Res Int; Zigangirova NA, et al. 2016. J Med Microbiol
Tsarenko SV, et al. 2023. J Antibiot (Tokyo)
Sheremet AB, et al. 2018. Biomed Res Int
Nesterenko LN, et al. 2016. J Antibiot (Tokyo); Zigangirova NA, et al. 2021. J Antibiot (Tokyo)
N-(4-cyanophenyl)-2-fluoro-N'-(4-phenoxyphenyl)propanediamide Depiction based on curated SMILES O N N H O F O HN Pseudomonas Biofilm Preclinical (in vivo) Singh VK, et al. 2022. Nat Commun
ML364 Depiction based on curated SMILES S F F F S O O HN H 3 C O N H N Klebsiella
Pseudomonas
Staphylococcus		 Biofilm; Biofilm
Pyocyanin
Biofilm		 Preclinical (in vivo)
Preclinical (in vivo)
Preclinical (in vivo)		 Zhang Y, et al. 2022. Front Microbiol
5beta,6alpha-Bis[4-(4-methoxyphenyl)-1H-1,2,3-triazole-1-ylmethyl]-4,5,6,7-tetrahydro-1H-benzoimidazole-2-amine Depiction based on curated SMILES N N N O CH 3 N H H 2 N N N N N O H 3 C Pseudomonas Biofilm Preclinical (in vitro) Huigens RW 3rd, et al. 2009. Org Biomol Chem
2-fluoro-N-(4-phenoxyphenyl)-N'-[4-(trifluoromethyl)phenyl]propanediamide Depiction based on curated SMILES O F F F F NH O N H O Pseudomonas Biofilm Preclinical (in vitro) Singh VK, et al. 2022. Nat Commun
3-(2-amino-1H-imidazol-5-yl)-N-(4-phenylbutyl)propanamide;hydrochloride Depiction based on curated SMILES ClH NH 2 HN N O NH Pseudomonas Biofilm Preclinical (in vitro) Ballard TE, et al. 2008. Chemistry
3-(2-amino-1H-imidazol-5-yl)-N-[2-(4-bromophenyl)ethyl]propanamide;hydrochloride Depiction based on curated SMILES O ClH Br NH 2 HN N NH Pseudomonas Biofilm Preclinical (in vitro) Ballard TE, et al. 2008. Chemistry
4-phenyl-1,4-dihydroindeno[1,2-d][1,3]thiazine-2,5-dione Depiction based on curated SMILES S O O HN Pseudomonas TTSS (Type III secretion system) Preclinical (in vitro) Harmon DE, et al. 2010. Antimicrob Agents Chemother
N'-(3-chloro-4-cyanophenyl)-N-(4-cyanophenyl)propanediamide Depiction based on curated SMILES N H Cl N N O O HN Pseudomonas Biofilm Preclinical (in vitro) Singh VK, et al. 2022. Nat Commun
   


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