|
| (5E)-5-{[5-(2,4-dichlorophenyl)furan-2-yl]methylidene}-1-(3,5-dimethylphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione |
|
Clostridium
Streptococcus |
theta-toxin/PFO (Perfringolysin O)
Pneumolysin |
Preclinical (in vitro)
Preclinical (in vitro) |
Aziz UBA, et al. 2024. Nat Commun
|
|
| 11-(3-Methoxy-phenyl)-5,11-dihydro-10-thia-5-aza-dibenzo[a,g]azulen-12-one |
|
Clostridium |
TcdB (Toxin B) |
Preclinical (in vitro) |
Farrow MA, et al. 2020. ACS Chem Biol |
|
| 3-(4-nitrophenyl)furo[3,2-g]chromen-7-one |
|
Clostridium |
BoNT (Botulinum neurotoxin) |
Preclinical (in vitro) |
Patel KB, et al. 2018. Appl Environ Microbiol |
|
| 3-cyclohexyl-1-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-one |
|
Clostridium |
TcdB (Toxin B) |
Preclinical (in vitro) |
Farrow MA, et al. 2020. ACS Chem Biol |
|
| Amlodipine |
|
Clostridium |
TcdB (Toxin B) |
Preclinical (in vitro) |
Farrow MA, et al. 2020. ACS Chem Biol |
|
| 5-acetyl-3-amino-4-(4-bromophenyl)-6-methyl-4,7-dihydrothieno[2,3-b]pyridine-2-carboxamide |
|
Clostridium |
TcdB (Toxin B) |
Preclinical (in vitro) |
Farrow MA, et al. 2020. ACS Chem Biol |
|
| 5-{3-[(2,4-difluorophenoxy)methyl]-4-methoxybenzylidene}-2,4,6(1H,3H,5H)-pyrimidinetrione |
|
Clostridium
Streptococcus |
theta-toxin/PFO (Perfringolysin O)
Pneumolysin |
Preclinical (in vitro)
Preclinical (in vitro) |
Aziz UBA, et al. 2024. Nat Commun
|
|
| 5-{4-[(2,4-dichlorobenzyl)oxy]-3-ethoxybenzylidene}pyrimidine-2,4,6(1H,3H,5H)-trione |
|
Clostridium
Streptococcus |
theta-toxin/PFO (Perfringolysin O)
Pneumolysin |
Preclinical (in vitro)
Preclinical (in vitro) |
Aziz UBA, et al. 2024. Nat Commun
|
|
| 7,7-dimethyl-10-(1-naphthyl)-6,7,8,10-tetrahydro-5H-indeno[1,2-b]quinoline-9,11-dione |
|
Clostridium |
TcdB (Toxin B) |
Preclinical (in vitro) |
Farrow MA, et al. 2020. ACS Chem Biol |
|
| 9,9-dimethyl-6-(3-nitrophenyl)-5-(2,2,2-trifluoroacetyl)-6,8,10,11-tetrahydrobenzo[b][1,4]benzodiazepin-7-one |
|
Clostridium |
TcdB (Toxin B) |
Preclinical (in vitro) |
Farrow MA, et al. 2020. ACS Chem Biol |
|
| | | |
