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Anti-virulence compounds related to VFcategory Adherence
(total 80 related compounds in database, current show from 1 to 10)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
Sibofimloc Depiction based on curated SMILES HO HO HO HO O OH OH HO HO O N CH 3 O Escherichia Adherence Phase II trial Chevalier G, et al. 2021. Microbiome; Reinisch W, et al. 2022. J Gastroenterol Hepatol
7-[3-methyl-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-2H-isoquinolin-1-one Depiction based on curated SMILES N H OH OH OH OH O O O CH 3 Escherichia Type 1 fimbriae Preclinical (in vivo) Jarvis C, et al. 2016. ChemMedChem
(3R)-5-Oxo-6-(morpholinomethyl)-7-(1-naphthylmethyl)-8-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3beta-carboxylic acid lithium salt Depiction based on curated SMILES O _ O O N + Li N O H S Escherichia Type 1 fimbriae; P fimbriae Preclinical (in vivo) Pinkner JS, et al. 2006. Proc Natl Acad Sci U S A
(3R)-5-Oxo-6-(dimethylaminomethyl)-7-(1-naphthylmethyl)-8-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3beta-carboxylic acid lithium salt Depiction based on curated SMILES _ O N H 3 C N CH 3 + Li O H S O Escherichia Type 1 fimbriae; P fimbriae Preclinical (in vivo) Pinkner JS, et al. 2006. Proc Natl Acad Sci U S A
(3R)-5-Oxo-6-(dimethylaminomethyl)-7-methyl-8-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3beta-carboxylic acid lithium salt Depiction based on curated SMILES CH 3 H 3 C N _ O O + Li S H N O CH 3 Escherichia Type 1 fimbriae; P fimbriae Preclinical (in vivo) Pinkner JS, et al. 2006. Proc Natl Acad Sci U S A
(3R)-5-Oxo-6-(morpholinomethyl)-7-(1-naphthylmethyl)-8-cyclopropyl-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3beta-carboxylic acid lithium salt Depiction based on curated SMILES N O O N _ O O H S + Li Escherichia Type 1 fimbriae; P fimbriae Preclinical (in vivo) Pinkner JS, et al. 2006. Proc Natl Acad Sci U S A
N-methyl-3-[3-methyl-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]benzamide Depiction based on curated SMILES O OH OH HO HO H 3 C O CH 3 O NH Escherichia Type 1 fimbriae Preclinical (in vivo) Cusumano CK, et al. 2011. Sci Transl Med; Jarvis C, et al. 2016. ChemMedChem
Carfilzomib Depiction based on curated SMILES CH 3 H 3 C N H O HN O N O O CH 3 O O CH 3 NH CH 3 N H O Streptococcus Adherence Preclinical (in vivo) Manzer HS, et al. 2022. PLoS Pathog
ML346 Depiction based on curated SMILES O HN O N H O CH 3 O Streptococcus Adherence Preclinical (in vivo) Guan XN, et al. 2022. RSC Med Chem
Lapatinib Depiction based on curated SMILES O N NH F Cl S O O N H CH 3 O N Streptococcus Adherence Preclinical (in vivo) Manzer HS, et al. 2022. PLoS Pathog
   


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