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Compound category: Benzenoids
(total 18 related compounds in database, current show from 1 to 10)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
Fluorothiazinon Depiction based on curated SMILES OH O S F F H 3 C NH O N N O Acinetobacter
Chlamydia
Klebsiella
Pseudomonas
Salmonella		 Biofilm
TTSS (Type III secretion system)
Biofilm
TTSS (Type III secretion system)
TTSS (SPI-1 encode); TTSS (SPI-2 encode)		 Preclinical (in vivo)
Preclinical (in vivo)
Preclinical (in vitro)
Preclinical (in vivo)
Phase II trial		 Bondareva NE, et al. 2022. J Antibiot (Tokyo)
Zigangirova NA, et al. 2012. Acta Naturae; Koroleva EA, et al. 2015. Biomed Res Int; Zigangirova NA, et al. 2016. J Med Microbiol
Tsarenko SV, et al. 2023. J Antibiot (Tokyo)
Sheremet AB, et al. 2018. Biomed Res Int
Nesterenko LN, et al. 2016. J Antibiot (Tokyo); Zigangirova NA, et al. 2021. J Antibiot (Tokyo)
1-phenyl-3-[4-(phenylsulfamoyl)phenyl]thiourea Depiction based on curated SMILES NH S N H O HN O S Escherichia
Salmonella		 Regulation
QseBC		 Preclinical (in vivo)
Preclinical (in vivo)		 Rasko DA, et al. 2008. Science
({1-[2-(2-fluorophenyl)ethyl]-4-piperidinyl}methyl)methyl(3-thienylmethyl)amine Depiction based on curated SMILES S F CH 3 N N Salmonella Biofilm Preclinical (in vivo) Woolard KJ, et al. 2022. Eur J Med Chem
Dephostatin Depiction based on curated SMILES CH 3 N OH HO N O Salmonella PmrAB; SsrAB Preclinical (in vivo) Tsai CN, et al. 2020. Cell Chem Biol
Compound 7b
(internal name in literature)		 Depiction based on curated SMILES N Cl Cl CH 3 S N Salmonella Biofilm Preclinical (in vivo) Woolard KJ, et al. 2022. Eur J Med Chem
Compound 7d
(internal name in literature)		 Depiction based on curated SMILES N Br Br CH 3 S N Salmonella Biofilm Preclinical (in vivo) Woolard KJ, et al. 2022. Eur J Med Chem
Compound 8j
(internal name in literature)		 Depiction based on curated SMILES CH 3 N S N Salmonella Biofilm Preclinical (in vivo) Woolard KJ, et al. 2022. Eur J Med Chem
(2Z,5Z)-5-(4-hydroxy-3,5-dimethoxybenzylidene)-3-phenyl-2-(phenylimino)-1,3-thiazolidin-4-one Depiction based on curated SMILES OH CH 3 O O N H 3 C N S O Salmonella
Yersinia		 TTSS (SPI-1 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Felise HB, et al. 2008. Cell Host Microbe
Mitoxantrone hydrochloride Depiction based on curated SMILES O OH OH HN NH OH ClH ClH HN HN OH O Salmonella Invasion Preclinical (in vitro) Ridge Y, et al. 2018. J Appl Microbiol
Sepantronium bromide Depiction based on curated SMILES _ Br N N O CH 3 O H 3 C O N + N Escherichia
Salmonella		 TTSS secreted effectors
TTSS-2 secreted effectors		 Phase II trial
Preclinical (in vitro)		 El Qaidi S, et al. 2018. Front Cell Infect Microbiol; Zhu C, et al. 2021. Pathogens
   


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