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Compound category: Organoheterocyclic compounds
(total 20 related compounds in database, current show from 11 to 20)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
7-methoxy-4-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}-5H-pyrimido[5,4-b]indole Depiction based on curated SMILES N N CH 3 N N HN O Salmonella Biofilm Preclinical (in vitro) Robijns SC, et al. 2012. FEMS Immunol Med Microbiol
7-methyl-4-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}-5H-pyrimido[5,4-b]indole Depiction based on curated SMILES N N CH 3 N N NH Salmonella Biofilm Preclinical (in vitro) Robijns SC, et al. 2012. FEMS Immunol Med Microbiol
8-fluoro-4-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}-5H-pyrimido[5,4-b]indole Depiction based on curated SMILES N N F N N N H Salmonella Biofilm Preclinical (in vitro) Robijns SC, et al. 2012. FEMS Immunol Med Microbiol
9-methoxy-4-{4-[(2E)-3-phenylprop-2-en-1-yl]piperazin-1-yl}-5H-pyrimido[5,4-b]indole Depiction based on curated SMILES HN N CH 3 N N N O Salmonella Biofilm Preclinical (in vitro) Robijns SC, et al. 2012. FEMS Immunol Med Microbiol
Pirlindole mesylate Depiction based on curated SMILES HO O O S CH 3 CH 3 HN N Salmonella Invasion Preclinical (in vitro) Ridge Y, et al. 2018. J Appl Microbiol
Fenbendazole Depiction based on curated SMILES S CH 3 N H N N H O O Salmonella Invasion Preclinical (in vitro) Ridge Y, et al. 2018. J Appl Microbiol
N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide Depiction based on curated SMILES F F F N H O N N CH 3 N N H Acinetobacter
Salmonella		 Biofilm
Biofilm		 Preclinical (in vitro)
Preclinical (in vitro)		 Moshiri J, et al. 2018. Front Microbiol
(E)-N'-(3,5-Dibromo-2-hydroxybenzylidene)nicotinohydrazide Depiction based on curated SMILES N OH Br O Br N N H Chlamydia
Escherichia
Salmonella		 TTSS (Type III secretion system)
TTSS (Type III secretion system)
TTSS (SPI-1 encode); TTSS (SPI-2 encode)		 Preclinical (in vitro)
Preclinical (in vitro)
Preclinical (in vitro)		 Bailey L, et al. 2007. FEBS Lett
Tree JJ, et al. 2009. Infect Immun; Wang D, et al. 2011. J Biol Chem
Negrea A, et al. 2007. Antimicrob Agents Chemother
Nicotinic acid (5-bromo-2-hydroxy-benzylidene)-hydrazide Depiction based on curated SMILES N OH O Br N N H Salmonella
Shigella		 TTSS (SPI-1 encode); TTSS (SPI-2 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Negrea A, et al. 2007. Antimicrob Agents Chemother
Veenendaal AK, et al. 2009. J Bacteriol
N-[2-[4-(benzimidazol-1-yl)anilino]-2-oxoethyl]-3-chloro-1-benzothiophene-2-carboxamide Depiction based on curated SMILES N H N N O S Cl O N H Salmonella
Yersinia		 TTSS (SPI-1 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vivo)		 Boonyom R, et al. 2022. J Genet Eng Biotechnol
Swietnicki W, et al. 2011. PLoS One
   


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