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Compound category: Organoheterocyclic compounds
(total 19 related compounds in database, current show from 11 to 19)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
2-phenyl-2,3-dihydrophthalazine-1,4-dione Depiction based on curated SMILES O O N HN Shigella VirF Preclinical (in vitro) Hurt JK, et al. 2010. J Biomol Screen
4-Morpholinoaniline Depiction based on curated SMILES NH 2 N O Salmonella
Shigella		 TTSS (SPI-1 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 McShan AC, et al. 2016. ChemMedChem
Dey S, et al. 2017. ChemMedChem
5-chloro-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-(ethylsulfonyl)-4-pyrimidinecarboxamide Depiction based on curated SMILES N H Cl N S CH 3 O N N O O S Shigella VirF Preclinical (in vitro) Emanuele AA, et al. 2014. J Antibiot (Tokyo); Emanuele AA, et al. 2015. PLoS One
5-Chloro-2-phenoxymethyl-1H-benzoimidazole Depiction based on curated SMILES O Cl N H N Shigella VirF Preclinical (in vitro) Emanuele AA, et al. 2014. J Antibiot (Tokyo); Emanuele AA, et al. 2015. PLoS One
CCG-21496 Depiction based on curated SMILES N N H OH N CH 3 Shigella VirF Preclinical (in vitro) Hurt JK, et al. 2010. J Biomol Screen
N,N-dimethyl-2-[(2-phenyl-[1]benzofuro[3,2-d]pyrimidin-4-yl)oxy]ethanamine Depiction based on curated SMILES O H 3 C N N O CH 3 N Shigella VirF Preclinical (in vitro) Emanuele AA, et al. 2014. J Antibiot (Tokyo); Emanuele AA, et al. 2015. PLoS One
Nicotinic acid (5-bromo-2-hydroxy-benzylidene)-hydrazide Depiction based on curated SMILES N OH O Br N N H Salmonella
Shigella		 TTSS (SPI-1 encode); TTSS (SPI-2 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Negrea A, et al. 2007. Antimicrob Agents Chemother
Veenendaal AK, et al. 2009. J Bacteriol
N-[4-(2-oxo-3,4-dihydro-1H-quinolin-6-yl)-1,3-thiazol-2-yl]-3-(1,3-thiazol-4-ylmethoxy)benzamide Depiction based on curated SMILES N H N N S O O O N H S Shigella TTSS (Type III secretion system) Preclinical (in vitro) Case HB, et al. 2018. Biochemistry
[2-[2-(methylcarbamoyl)-2,3-dihydro-1,4-benzoxazin-4-yl]-2-oxoethyl] 2-thiophen-2-ylquinoline-4-carboxylate Depiction based on curated SMILES S N O NH O N O CH 3 O O Shigella TTSS (Type III secretion system) Preclinical (in vitro) Case HB, et al. 2018. Biochemistry
   
   
   


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