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Compound category: Organoheterocyclic compounds
(total 19 related compounds in database, current show from 1 to 10)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
4-methyl-2-(4-methylphenyl)-6-{5-[(4-phenylpiperazin-1-yl)carbonyl]-1,2,4-oxadiazol-3-yl}-1,2,4-triazine-3,5(2H,4H)-dione Depiction based on curated SMILES N N O N CH 3 O N N N CH 3 O O N Shigella TTSS (Type III secretion system) Preclinical (in vivo) Case HB, et al. 2020. Biochemistry
4-methyl-2-phenyl-6-{5-[(4-phenylpiperazin-1-yl)carbonyl]-1,2,4-oxadiazol-3-yl}-1,2,4-triazine-3,5(2H,4H)-dione Depiction based on curated SMILES N N N O N O N O CH 3 O N N Shigella TTSS (Type III secretion system) Preclinical (in vivo) Case HB, et al. 2020. Biochemistry
6-(4-((2,4-dimethylphenyl)sulfonyl)piperazin-1-yl)-N-(pyridin-4-yl)pyridazin-3-amine Depiction based on curated SMILES N N N N H CH 3 N N O O S CH 3 Shigella TTSS (Type III secretion system) Preclinical (in vivo) Case HB, et al. 2020. Biochemistry
N-(1,3-benzodioxol-5-ylmethyl)-1-[(2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-7-yl)sulfonyl]-4-piperidinecarboxamide Depiction based on curated SMILES O O HN N H O S O O N O Shigella TTSS (Type III secretion system) Preclinical (in vivo) Case HB, et al. 2020. Biochemistry
N-(furan-2-ylmethylcarbamoyl)-2-(4-oxobenzo[g]quinazolin-3-yl)acetamide Depiction based on curated SMILES O N H O HN O O N N Shigella TTSS (Type III secretion system) Preclinical (in vivo) Case HB, et al. 2020. Biochemistry
[2-[[(1R,2R)-2-methylcyclohexyl]carbamoylamino]-2-oxoethyl] 4-oxo-3-phenylphthalazine-1-carboxylate Depiction based on curated SMILES N N O O N H H H H 3 C O N H O O Shigella TTSS (Type III secretion system) Preclinical (in vivo) Case HB, et al. 2020. Biochemistry
1'-butyl-4'-(nitromethyl)-1',4'-dihydro-2,3'-biquinoline Depiction based on curated SMILES _ O O + N H 3 C N N Shigella VirF Preclinical (in vitro) Koppolu V, et al. 2013. Infect Immun
5-Hydroxyindole Depiction based on curated SMILES OH N H Salmonella
Shigella		 TTSS (SPI-1 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 McShan AC, et al. 2016. ChemMedChem
Dey S, et al. 2017. ChemMedChem
4-Aminoquinaldine Depiction based on curated SMILES CH 3 NH 2 N Shigella TTSS (Type III secretion system) Preclinical (in vitro) Dey S, et al. 2017. ChemMedChem
3,5-di(3-pyridylmethyl)-1,3,5-thiadiazinane-2-thione Depiction based on curated SMILES N N S S N N Shigella VirF Preclinical (in vitro) Hurt JK, et al. 2010. J Biomol Screen
   


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