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Compound category: Organoheterocyclic compounds
(total 34 related compounds in database, current show from 11 to 20)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
(E)-3-(4-fluorophenyl)-N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]prop-2-enamide Depiction based on curated SMILES HO N _ O O + N N O N H F Pseudomonas
Yersinia
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)
Preclinical (in vivo)		 Marsden AE, et al. 2016. Antimicrob Agents Chemother
Kim OK, et al. 2009. J Med Chem
Garrity-Ryan LK, et al. 2010. Infect Immun
(E)-N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]-3-(4-methoxyphenyl)prop-2-enamide Depiction based on curated SMILES _ O O + N OH N N CH 3 N H O O Yersinia TTSS (Type III secretion system) Preclinical (in vitro) Kim OK, et al. 2009. J Med Chem
1,3-dioxo-2-[4-(4-phenylquinazolin-2-yl)phenyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid Depiction based on curated SMILES N O O O HO N N Yersinia TTSS secreted effectors Preclinical (in vitro) Eriksson J, et al. 2012. Adv Exp Med Biol
1,6-dimethyl-3-(thiophen-2-yl)pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione Depiction based on curated SMILES H 3 C S N N CH 3 O N O N N Yersinia TTSS secreted effectors Preclinical (in vitro) Hu X, et al. 2013. Bioorg Med Chem Lett
1-{(E)-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)imino]methyl}naphthalen-2-ol Depiction based on curated SMILES N OH H 3 C CH 3 N N Pseudomonas
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Harmon DE, et al. 2010. Antimicrob Agents Chemother
1-[(5Z)-5-(1-butyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-4,5-dihydro-1,3-thiazol-2-yl]piperidine-4-carboxamide Depiction based on curated SMILES O N O H 2 N H 3 C N S O N Yersinia TTSS secreted effectors Preclinical (in vitro) Hu X, et al. 2013. Bioorg Med Chem Lett
2,6-bis[4-(4-aminophenyl)sulfonylphenyl]pyrrolo[3,4-f]isoindole-1,3,5,7-tetrone Depiction based on curated SMILES N S O O O NH 2 O N S O O NH 2 O O Yersinia TTSS secreted effectors Preclinical (in vitro) Eriksson J, et al. 2012. Adv Exp Med Biol
2,8-bis(5-methyl-2-furyl)pyrido[3,2-g]quinoline-4,6-dicarboxylic acid Depiction based on curated SMILES O OH O O H 3 C N N CH 3 OH O Yersinia TTSS secreted effectors Preclinical (in vitro) Eriksson J, et al. 2012. Adv Exp Med Biol
2-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)iminoindene-1,3-dione Depiction based on curated SMILES H 3 C N N O O H 3 C O N Yersinia TTSS secreted effectors Preclinical (in vitro) Hu X, et al. 2013. Bioorg Med Chem Lett
2-hydroxy-5-{5-[(E)-{2-[(5-phenyl-2H-tetrazol-2-yl)acetyl]hydrazinylidene}methyl]furan-2-yl}benzoic acid Depiction based on curated SMILES OH O HO O N N H O N N N N Yersinia TTSS secreted effectors Preclinical (in vitro) Tautz L, et al. 2005. J Biol Chem
   


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