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Compound category: Organoheterocyclic compounds
(total 322 related compounds in database, current show from 251 to 260)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide Depiction based on curated SMILES F F F N H O N N CH 3 N N H Acinetobacter
Salmonella		 Biofilm
Biofilm		 Preclinical (in vitro)
Preclinical (in vitro)		 Moshiri J, et al. 2018. Front Microbiol
(E)-N'-(3,5-Dibromo-2-hydroxybenzylidene)nicotinohydrazide Depiction based on curated SMILES N OH Br O Br N N H Chlamydia
Escherichia
Salmonella		 TTSS (Type III secretion system)
TTSS (Type III secretion system)
TTSS (SPI-1 encode); TTSS (SPI-2 encode)		 Preclinical (in vitro)
Preclinical (in vitro)
Preclinical (in vitro)		 Bailey L, et al. 2007. FEBS Lett
Tree JJ, et al. 2009. Infect Immun; Wang D, et al. 2011. J Biol Chem
Negrea A, et al. 2007. Antimicrob Agents Chemother
Nicotinic acid (5-bromo-2-hydroxy-benzylidene)-hydrazide Depiction based on curated SMILES N OH O Br N N H Salmonella
Shigella		 TTSS (SPI-1 encode); TTSS (SPI-2 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Negrea A, et al. 2007. Antimicrob Agents Chemother
Veenendaal AK, et al. 2009. J Bacteriol
N-[2-[4-(benzimidazol-1-yl)anilino]-2-oxoethyl]-3-chloro-1-benzothiophene-2-carboxamide Depiction based on curated SMILES N H N N O S Cl O N H Salmonella
Yersinia		 TTSS (SPI-1 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vivo)		 Boonyom R, et al. 2022. J Genet Eng Biotechnol
Swietnicki W, et al. 2011. PLoS One
1'-butyl-4'-(nitromethyl)-1',4'-dihydro-2,3'-biquinoline Depiction based on curated SMILES _ O O + N H 3 C N N Shigella VirF Preclinical (in vitro) Koppolu V, et al. 2013. Infect Immun
4-Aminoquinaldine Depiction based on curated SMILES CH 3 NH 2 N Shigella TTSS (Type III secretion system) Preclinical (in vitro) Dey S, et al. 2017. ChemMedChem
3,5-di(3-pyridylmethyl)-1,3,5-thiadiazinane-2-thione Depiction based on curated SMILES N N S S N N Shigella VirF Preclinical (in vitro) Hurt JK, et al. 2010. J Biomol Screen
2-phenyl-2,3-dihydrophthalazine-1,4-dione Depiction based on curated SMILES O O N HN Shigella VirF Preclinical (in vitro) Hurt JK, et al. 2010. J Biomol Screen
5-chloro-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-(ethylsulfonyl)-4-pyrimidinecarboxamide Depiction based on curated SMILES N H Cl N S CH 3 O N N O O S Shigella VirF Preclinical (in vitro) Emanuele AA, et al. 2014. J Antibiot (Tokyo); Emanuele AA, et al. 2015. PLoS One
5-Chloro-2-phenoxymethyl-1H-benzoimidazole Depiction based on curated SMILES O Cl N H N Shigella VirF Preclinical (in vitro) Emanuele AA, et al. 2014. J Antibiot (Tokyo); Emanuele AA, et al. 2015. PLoS One
   


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