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Compound category: Azoles
(total 10 related compounds in database)
 
Compound name 2D structure Target pathogen(s) Related VF/VFcategory Max phase Reference(s)
N-[2-[4-(benzimidazol-1-yl)anilino]-2-oxoethyl]-3-chloro-1-benzothiophene-2-carboxamide Depiction based on curated SMILES N H N N O S Cl O N H Salmonella
Yersinia		 TTSS (SPI-1 encode)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vivo)		 Boonyom R, et al. 2022. J Genet Eng Biotechnol
Swietnicki W, et al. 2011. PLoS One
N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]-4-(1,3-oxazol-5-yl)benzamide Depiction based on curated SMILES HO N N + N O _ O N H O O N Yersinia TTSS (Type III secretion system) Preclinical (in vivo) Garrity-Ryan LK, et al. 2010. Infect Immun
(2Z)-2-(3-chloro-5-ethoxy-4-hydroxybenzylidene)-7,8-dimethyl[1,3]thiazolo[3,2-a]benzimidazol-3(2H)-one Depiction based on curated SMILES H 3 C OH Cl O N H 3 C CH 3 N S O Pseudomonas
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Harmon DE, et al. 2010. Antimicrob Agents Chemother
(E)-3-(4-fluorophenyl)-N-[4-(1-hydroxy-5-methyl-6-nitrobenzimidazol-2-yl)phenyl]prop-2-enamide Depiction based on curated SMILES O N H 3 C + N _ O N OH H F O N Yersinia TTSS (Type III secretion system) Preclinical (in vitro) Kim OK, et al. 2009. J Med Chem
(E)-3-(4-fluorophenyl)-N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]prop-2-enamide Depiction based on curated SMILES HO N _ O O + N N O N H F Pseudomonas
Yersinia
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)
Preclinical (in vivo)		 Marsden AE, et al. 2016. Antimicrob Agents Chemother
Kim OK, et al. 2009. J Med Chem
Garrity-Ryan LK, et al. 2010. Infect Immun
(E)-N-[4-(1-hydroxy-6-nitrobenzimidazol-2-yl)phenyl]-3-(4-methoxyphenyl)prop-2-enamide Depiction based on curated SMILES _ O O + N OH N N CH 3 N H O O Yersinia TTSS (Type III secretion system) Preclinical (in vitro) Kim OK, et al. 2009. J Med Chem
1-{(E)-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)imino]methyl}naphthalen-2-ol Depiction based on curated SMILES N OH H 3 C CH 3 N N Pseudomonas
Yersinia		 TTSS (Type III secretion system)
TTSS (Type III secretion system)		 Preclinical (in vitro)
Preclinical (in vitro)		 Harmon DE, et al. 2010. Antimicrob Agents Chemother
2-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)iminoindene-1,3-dione Depiction based on curated SMILES H 3 C N N O O H 3 C O N Yersinia TTSS secreted effectors Preclinical (in vitro) Hu X, et al. 2013. Bioorg Med Chem Lett
2-hydroxy-5-{5-[(E)-{2-[(5-phenyl-2H-tetrazol-2-yl)acetyl]hydrazinylidene}methyl]furan-2-yl}benzoic acid Depiction based on curated SMILES OH O HO O N N H O N N N N Yersinia TTSS secreted effectors Preclinical (in vitro) Tautz L, et al. 2005. J Biol Chem
5-[3'-(4-methylphenyl)-1'-phenyl-5-(2-thienyl)-3,4-dihydro-1'H,2H-3,4'-bipyrazol-2-yl]-5-oxopentanoic acid Depiction based on curated SMILES O S N N O OH N N CH 3 Yersinia TTSS (Type III secretion system) Preclinical (in vitro) Pan NJ, et al. 2009. Antimicrob Agents Chemother
   


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