|
(2Z,5Z)-5-(4-hydroxy-3,5-dimethoxybenzylidene)-3-phenyl-2-(phenylimino)-1,3-thiazolidin-4-one |
|
Salmonella Yersinia |
TTSS (SPI-1 encode) TTSS (Type III secretion system) |
Preclinical (in vitro) Preclinical (in vitro) |
Felise HB, et al. 2008. Cell Host Microbe
|
|
Mitoxantrone hydrochloride |
Depiction based on curated SMILES
O
OH
OH
HN
NH
OH
ClH
ClH
HN
HN
OH
O
|
Salmonella |
Invasion |
Preclinical (in vitro) |
Ridge Y, et al. 2018. J Appl Microbiol |
|
Sepantronium bromide |
Depiction based on curated SMILES
_
Br
N
N
O
CH
3
O
H
3
C
O
N
+
N
|
Escherichia Salmonella |
TTSS secreted effectors TTSS-2 secreted effectors |
Phase II trial Preclinical (in vitro) |
El Qaidi S, et al. 2018. Front Cell Infect Microbiol; Zhu C, et al. 2021. Pathogens
|
|
Propofol |
Depiction based on curated SMILES
CH
3
H
3
C
CH
3
CH
3
OH
|
Salmonella |
Invasion |
Preclinical (in vitro) |
Ridge Y, et al. 2018. J Appl Microbiol |
|
Mefenamic acid |
Depiction based on curated SMILES
H
3
C
HO
O
CH
3
N
H
|
Salmonella |
Invasion |
Preclinical (in vitro) |
Ridge Y, et al. 2018. J Appl Microbiol |
|
3,4-DIMETHYLBENZOIC ACID |
Depiction based on curated SMILES
CH
3
O
HO
CH
3
|
Salmonella |
TTSS (SPI-1 encode) |
Preclinical (in vitro) |
Peixoto RJM, et al. 2017. Appl Environ Microbiol |
|
4-chloro-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide |
Depiction based on curated SMILES
Cl
O
OH
N
N
H
|
Chlamydia Salmonella Shigella |
TTSS (Type III secretion system) TTSS (SPI-1 encode); TTSS (SPI-2 encode) TTSS (Type III secretion system) |
Preclinical (in vitro) Preclinical (in vitro) Preclinical (in vitro) |
Muschiol S, et al. 2006. Proc Natl Acad Sci U S A Negrea A, et al. 2007. Antimicrob Agents Chemother Veenendaal AK, et al. 2009. J Bacteriol |
|
(E)-N'-(2,3,4-Trihydroxybenzylidene)benzohydrazide |
Depiction based on curated SMILES
OH
OH
O
HO
N
N
H
|
Escherichia Salmonella |
TTSS (Type III secretion system) TTSS (SPI-1 encode); TTSS (SPI-2 encode) |
Preclinical (in vitro) Preclinical (in vitro) |
Tree JJ, et al. 2009. Infect Immun; Wang D, et al. 2011. J Biol Chem Negrea A, et al. 2007. Antimicrob Agents Chemother |
|
N-[(E)-(2,3,4-trihydroxyphenyl)methylideneamino]furan-2-carboxamide |
Depiction based on curated SMILES
HO
O
OH
HO
O
N
N
H
|
Salmonella Shigella |
TTSS (SPI-1 encode); TTSS (SPI-2 encode) TTSS (Type III secretion system) |
Preclinical (in vitro) Preclinical (in vitro) |
Negrea A, et al. 2007. Antimicrob Agents Chemother Veenendaal AK, et al. 2009. J Bacteriol |
|
N'-(3,5-Dibromosalicylidene)-4-nitrobenzhydrazide |
Depiction based on curated SMILES
Br
_
O
O
+
N
HO
O
Br
N
N
H
|
Salmonella Yersinia |
TTSS (SPI-1 encode); TTSS (SPI-2 encode) TTSS (Type III secretion system) |
Preclinical (in vitro) Preclinical (in vitro) |
Negrea A, et al. 2007. Antimicrob Agents Chemother Kauppi AM, et al. 2003. Chem Biol; Nordfelth R, et al. 2005. Infect Immun |
|
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