|
(3Z)-5-bromo-3-{4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}-1,3-dihydro-2H-indol-2-one |
|
Yersinia |
TTSS secreted effectors |
Preclinical (in vitro) |
Hu X, et al. 2013. Bioorg Med Chem Lett |
|
5-cyano-6-[(4-methylphenyl)methylsulfanyl]pyridine-2-carboxylic acid |
Depiction based on curated SMILES
N
N
HO
O
CH
3
S
|
Escherichia Yersinia |
TTSS (Type III secretion system) TTSS (Type III secretion system) |
Preclinical (in vitro) Preclinical (in vitro) |
Pan NJ, et al. 2009. Antimicrob Agents Chemother
|
|
5-[3'-(4-methylphenyl)-1'-phenyl-5-(2-thienyl)-3,4-dihydro-1'H,2H-3,4'-bipyrazol-2-yl]-5-oxopentanoic acid |
Depiction based on curated SMILES
O
S
N
N
O
OH
N
N
CH
3
|
Yersinia |
TTSS (Type III secretion system) |
Preclinical (in vitro) |
Pan NJ, et al. 2009. Antimicrob Agents Chemother |
|
5-[5-[(E)-3-[[(1S)-1-carboxy-2-(4-nitrophenyl)ethyl]amino]-3-oxoprop-1-enyl]furan-2-yl]-2-hydroxybenzoic acid |
Depiction based on curated SMILES
+
N
O
N
H
O
_
O
O
OH
O
O
OH
OH
|
Yersinia |
TTSS secreted effectors |
Preclinical (in vitro) |
Leone M, et al. 2010. Chem Biol Drug Des |
|
5-[5-[(E)-3-[[3-[[4-(3,4-difluorophenyl)-1,3-thiazol-2-yl]amino]-3-oxopropyl]amino]-3-oxoprop-1-enyl]furan-2-yl]-2-hydroxybenzoic acid |
Depiction based on curated SMILES
O
N
H
N
N
H
F
F
S
O
O
OH
HO
O
|
Yersinia |
TTSS secreted effectors |
Preclinical (in vitro) |
Leone M, et al. 2010. Chem Biol Drug Des |
|
(Z)-5-(5-((2,4-dioxothiazolidin-5-ylidene)methyl)furan-2-yl)-2-hydroxybenzoic acid |
Depiction based on curated SMILES
S
O
OH
HO
O
O
O
HN
|
Yersinia |
TTSS secreted effectors |
Preclinical (in vitro) |
Tautz L, et al. 2005. J Biol Chem |
|
5-[5-(2,3-Dihydro-6,7-dimethyl-3-oxothiazolo[3,2-a]benzimidazole-2-ylidenemethyl)-2-furanyl]-2-hydroxybenzoic acid |
Depiction based on curated SMILES
N
S
HO
O
OH
O
CH
3
O
N
CH
3
|
Yersinia |
TTSS secreted effectors |
Preclinical (in vitro) |
Tautz L, et al. 2005. J Biol Chem |
|
5-[5-[(Z)-[[6-(4-fluoroanilino)-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-yl]hydrazinylidene]methyl]furan-2-yl]-2-hydroxybenzoic acid |
Depiction based on curated SMILES
O
N
HO
O
OH
F
NH
N
N
O
N
N
NH
|
Yersinia |
TTSS secreted effectors |
Preclinical (in vitro) |
Hu X, et al. 2013. Bioorg Med Chem Lett |
|
5-({1-[(2-chloro-1,3-thiazol-5-yl)methyl]-1H-indol-3-yl}methylene)-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione |
Depiction based on curated SMILES
Cl
O
CH
3
N
O
S
H
3
C
N
N
O
N
|
Yersinia |
TTSS secreted effectors |
Preclinical (in vitro) |
Hu X, et al. 2013. Bioorg Med Chem Lett |
|
5-({(E)-[2-(4-chlorophenyl)-5-oxo-1,3-oxazol-4(5H)-ylidene]methyl}amino)-2-hydroxybenzoic acid |
Depiction based on curated SMILES
HO
O
O
Cl
O
N
N
H
HO
|
Yersinia |
TTSS secreted effectors |
Preclinical (in vitro) |
Hu X, et al. 2013. Bioorg Med Chem Lett |
|
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